Endocrine Abstracts

Alterations in gene expression are a fundamental component of diabetes. These may be occur as a result of specific genetic alterations that underlie diabetes, due to a lack of insulin signaling as a result of insulin deficiency or insulin resistance, or be secondary to the hyperglycemia and altered metabolic state that occurs in diabetes. To help determine which alterations in diabetes are the result of decreased or absent insulin action in tissues or secondary to the metaboli...